When shipping using FedEx Web Services in SendSuite® Live, the error "System.Web.Services.Protocols.SoapException: Internal Server Error" is displayed.
This is caused by an issue with the FedEx Web Servers. Most likely the fedex.com servers are down.
FedEx should have the servers back up within a short amount of time. You can contact FedEx support directly for an update, or contact Pitney Bowes software support.
UPDATED: October 05, 2016